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Cat. No.: HY-P990869

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Anti-CD1a Antibody (OKT-6)

Anti-CD1a Antibody (OKT-6) is an anti-human CD1a IgG1 monoclonal antibody. Anti-CD1a Antibody (OKT-6) blocks T cell activation by blocking CD1a function. Anti-CD1a Antibody (OKT-6) can reduce the production of IFN-γ. Anti-CD1a Antibody (OKT-6) can be used for researches on cancer and inflammation such as leukemia. The recommend isotype control of Anti-CD1a Antibody (OKT-6): Mouse IgG1 kappa, Isotype Control (HY-P99977).

For research use only. We do not sell to patients.

Molecular Weight:150 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (260 KB)

Anti-CD1a Antibody (OKT-6) Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Mouse IgG1 kappa

Recommend Isotype Controls

Mouse IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target^[1]^[2]

CD1a

IL-13

IL-22

All Interleukin Related Isoforms :

In Vitro

Anti-CD1a Antibody (OKT-6) (10 μg/mL) significantly inhibits IFN-γ production induced by bee venom or phospholipase A2 (PLA2) in K562-CD1a cells^[1].
Anti-CD1a Antibody (OKT-6) (10 μg/mL) can block PLA2 or bee venom induced T cell activation^[1].
Anti-CD1a Antibody (OKT-6) (10 μg/mL, 1 h) significantly inhibits the production of IFN-γ and IL-22 induced by house dust mite (HDM), PLA2G4A, or S. aureus in group 2 innate lymphoid cells (ILC2)^[2].
Anti-CD1a Antibody (OKT-6) (10 μg/mL) inhibits the production of IL-13 by T cells and T cell activation induced by S. aureus^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[2]

Cell Line:

Preprocess ILC2 for 1 h, subsequently co-cultured with T cells for 24 h
Concentration:

10 μg/mL
Incubation Time:

1 h
Result:

Significantly reduced the levels of IFN-γ and IL-22.

Gene ID

909 [NCBI]

Accession

P06126

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

in vitro CD1a blockade; Flow cytometry

Chemical Information

Molecular Weight 150 kDa
SMILES

[Anti-CD1a Antibody (OKT-6)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Bourgeois EA, et al. Bee venom processes human skin lipids for presentation by CD1a. J Exp Med. 2015 Feb 9;212(2):149-63. [Content Brief]

[2]. Hardman CS, et al. CD1a presentation of endogenous antigens by group 2 innate lymphoid cells. Sci Immunol. 2017 Dec 22;2(18):eaan5918. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
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Purity:
Quantity:

Anti-CD1a Antibody (OKT-6)

Bradford Protein Assay Kit

Protein A Agarose

Cell-ATP Viability Detection Kit

HOLO Human Interleukin-2 (IL-2) Detection Kit

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

All Interleukin Related Isoforms