RHEX - regulator of hemoglobinization and erythroid cell expansion Gene

Also Known as C1orf186

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 440712

About RHEX

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,053,173-206,102,449 (from NCBI)

This gene has 5 transcripts (splice variants) and 71 orthologues. Broad expression in endometrium (RPKM 4.0), gall bladder (RPKM 2.3) and 16 other tissues.

Summary

Enables erythropoietin receptor binding activity. Involved in erythropoietin-mediated signaling pathway and positive regulation of erythrocyte differentiation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RHEX Products (2)

mRNA Protein Name
NM_001007544.4 NP_001007545.1 regulator of hemoglobinization and erythroid cell expansion protein
NM_001369490.1 NP_001356419.1 regulator of hemoglobinization and erythroid cell expansion protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables erythropoietin receptor binding IDA
IDA: Inferred from direct assay
25092874 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25092874 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to erythropoietin IMP
IMP: Inferred from mutant phenotype
25092874 GOA
involved in erythropoietin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
25092874 GOA
involved in positive regulation of erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
25092874 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in plasma membrane IDA
IDA: Inferred from direct assay
25092874 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulator of hemoglobinization and erythroid cell expansion protein

  • regulator of human erythroid cell expansion protein

RHEX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RHEX Q6ZWK4 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32296183
Intra
RHEX Q6ZWK4 RBFA Homo sapiens Q8N0V3
Validated Y2H
32296183
Intra
RHEX Q6ZWK4 SH3GL1 Homo sapiens Q99961
Validated Y2H
32296183
Intra
RHEX Q6ZWK4 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gallbladder Benign Neoplasm
Gallbladder Adenoma
Biliary Tract Benign Neoplasm

  • Extrahepatic Bile Duct Neoplasm

  • Neoplasm Of Extrahepatic Bile Ducts

  • Tumor Of The Extrahepatic Bile Duct
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11943 RHEX Human Pre-designed siRNA Set A Pre-designed Set / Unkown