NLRC5 - NLR family CARD domain containing 5 Gene
Also Known as NOD4; NOD27; CLR16.1
Species: Homo sapiens
About NLRC5
This gene has 29 transcripts (splice variants), 169 orthologues and 20 paralogues. Broad expression in spleen (RPKM 23.6), lymph node (RPKM 20.1) and 22 other tissues.
Summary
NLRC5 Products (26)
| mRNA | Protein | Name |
|---|---|---|
| NM_001330552.2 | NP_001317481.1 | protein NLRC5 isoform 2 |
| NM_001384950.1 | NP_001371879.1 | protein NLRC5 isoform 1 |
| NM_001384951.1 | NP_001371880.1 | protein NLRC5 isoform 2 |
| NM_001384952.1 | NP_001371881.1 | protein NLRC5 isoform 3 |
| NM_001384953.1 | NP_001371882.1 | protein NLRC5 isoform 3 |
| NM_001384954.1 | NP_001371883.1 | protein NLRC5 isoform 4 |
| NM_001384955.1 | NP_001371884.1 | protein NLRC5 isoform 5 |
| NM_001384956.1 | NP_001371885.1 | protein NLRC5 isoform 6 |
| NM_001384957.1 | NP_001371886.1 | protein NLRC5 isoform 7 |
| NM_001384958.1 | NP_001371887.1 | protein NLRC5 isoform 8 |
| NM_001384959.1 | NP_001371888.1 | protein NLRC5 isoform 9 |
| NM_001384960.1 | NP_001371889.1 | protein NLRC5 isoform 10 |
| NM_001384961.1 | NP_001371890.1 | protein NLRC5 isoform 11 |
| NM_001384962.1 | NP_001371891.1 | protein NLRC5 isoform 11 |
| NM_001384963.1 | NP_001371892.1 | protein NLRC5 isoform 12 |
| NM_001384964.1 | NP_001371893.1 | protein NLRC5 isoform 12 |
| NM_001384965.1 | NP_001371894.1 | protein NLRC5 isoform 13 |
| NM_001384966.1 | NP_001371895.1 | protein NLRC5 isoform 14 |
| NM_001384967.1 | NP_001371896.1 | protein NLRC5 isoform 15 |
| NM_001384968.1 | NP_001371897.1 | protein NLRC5 isoform 16 |
| NM_001384969.1 | NP_001371898.1 | protein NLRC5 isoform 17 |
| NM_001384970.1 | NP_001371899.1 | protein NLRC5 isoform 18 |
| NM_001384971.1 | NP_001371900.1 | protein NLRC5 isoform 19 |
| NM_001384972.1 | NP_001371901.1 | protein NLRC5 isoform 20 |
| NM_001384973.1 | NP_001371902.1 | protein NLRC5 isoform 21 |
| NM_032206.5 | NP_115582.4 | protein NLRC5 isoform 1 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IDA
IDA: Inferred from direct assay
|
20639463 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
20434986 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
20061403 | GOA |
| located in cytosol |
IDA
IDA: Inferred from direct assay
|
20639463 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
20639463 | GOA |
NLRC5 Protein Structure
NACHT: NACHT domain (222 - 382)
LRR_6: Leucine Rich repeat (870 - 891)
LRR_6: Leucine Rich repeat (1008 - 1026)
LRR_6: Leucine Rich repeat (1521 - 1542)
LRR_6: Leucine Rich repeat (1578 - 1599)
LRR_4: Leucine Rich repeats (2 copies) (1606 - 1648)
- 0
- 300
- 600
- 900
- 1200
- 1500
- 1866 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein NLRC5 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Pityriasis Rubra Pilaris |
|
|
| Familial Pityriasis Rubra Pilaris |
|
|
| Bare Lymphocyte Syndrome, Type I |
|
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| Familial Mediterranean Fever |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | NLRC5 | RGD | RGD:1309166 |
| Canis familiaris | NLRC5 | VGNC | VGNC:43844 |
| Felis catus | NLRC5 | VGNC | VGNC:63828 |
| Macaca mulatta | NLRC5 | VGNC | VGNC:75285 |
| Bos taurus | NLRC5 | VGNC | VGNC:32114 |
| Mus musculus | NLRC5 | MGD | MGI:3612191 |
| Others | NLRC5 | NCBI |