UTF1 - undifferentiated embryonic cell transcription factor 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8433

About UTF1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,230,217-133,231,558 (from NCBI)

This gene has 1 transcript (splice variant), 48 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]

UTF1 Products (1)

mRNA Protein Name
NM_003577.3 NP_003568.2 undifferentiated embryonic cell transcription factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
9748258 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
9748258 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in male gonad development IEP
IEP: Inferred from expression pattern
18281244 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9748258 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nucleus IDA
IDA: Inferred from direct assay
18281244 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UTF1 Protein Structure

Myb_DNA-bind_4

Myb_DNA-bind_4: Myb/SANT-like DNA-binding domain (60 - 130)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
Protein Preferred Names Protein Names

undifferentiated embryonic cell transcription factor 1

UTF1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P810320 UTF1 Antibody WB, ICC/IF Human, Mouse, Rat
HY-P84634 UTF1 Antibody (YA4331) FC, ELISA Human
HY-P84634A UTF1 Antibody (YA4331)(PBS only) FC, ELISA Human

Related Diseases

Diseases Alias
Spermatocytoma

  • Spermatocytic Seminoma
Opportunistic Bacterial Infectious Disease
Nocardiosis

  • Nocardia Infection

  • Nocardia Infections

  • Nocardia Infectious Disease

  • Lung Nocardiosis

  • Nocardiasis

  • Nocardiosis Nos
Germ Cell And Embryonal Cancer

  • Germ Cell And Embryonal Neoplasm
Germ Cell Cancer

  • Malignant Germ Cell Tumor

  • Neoplasms, Germ Cell And Embryonal

  • Germ Cell Neoplasm

  • Germ Cell Tumour

  • Malignant Tumor Of The Germ Cell

  • Neoplasms Germ Cell

  • Malignant Germ Cell Neoplasm
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS15574 UTF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22353 Utf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28875 Utf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UTF1 RGD RGD:1589375
Mus musculus UTF1 MGD MGI:1276125
Others UTF1 NCBI