ADAM21 - ADAM metallopeptidase domain 21 Gene

Also Known as ADAM31; ADAM 21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8747

About ADAM21

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,452,174-70,459,905 (from NCBI)

This gene has 2 transcripts (splice variants), 422 orthologues and 20 paralogues. Biased expression in testis (RPKM 6.0) and brain (RPKM 0.2).

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]

ADAM21 Products (1)

mRNA Protein Name
NM_003813.4 NP_003804.2 disintegrin and metalloproteinase domain-containing protein 21 preproprotein

ADAM21 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (41 - 159)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (209 - 398)

Disintegrin

Disintegrin: Disintegrin (415 - 489)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (492 - 607)

  • 0
  • 200
  • 400
  • 600
  • 722 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 21

  • ADAM metallopeptidase domain 21, preproprotein

ADAM21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ADAM21 Q9UKJ8 CNR2 Homo sapiens P34972
Y2H Prey Pooling
32296183
Intra
ADAM21 Q9UKJ8 CNR2 Homo sapiens P34972
Y2H Array
32296183
Intra
ADAM21 Q9UKJ8 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
ADAM21 Q9UKJ8 SGTA Homo sapiens O43765
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder With Short Stature And Behavioral Abnormalities

  • IDDSSBA
Developmental Coordination Disorder

  • Motor Skills Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00277 ADAM21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ADAM21 RGD RGD:6499950
Canis familiaris ADAM21 VGNC VGNC:37579
Bos taurus ADAM21 VGNC VGNC:55030
Mus musculus ADAM21 MGD MGI:1861229
Macaca mulatta ADAM21 VGNC VGNC:103783
Others ADAM21 NCBI