SNRNP40 - small nuclear ribonucleoprotein U5 subunit 40 Gene

Also Known as 40K; SPF38; WDR57; PRP8BP; HPRP8BP; PRPF8BP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9410

About SNRNP40

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,259,568-31,296,788 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 26 paralogues. Ubiquitous expression in lymph node (RPKM 17.2), testis (RPKM 14.1) and 25 other tissues.

Summary

This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008]

SNRNP40 Products (1)

mRNA Protein Name
NM_004814.3 NP_004805.2 U5 small nuclear ribonucleoprotein 40 kDa protein

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
9774689 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: Inferred from physical interaction
30975767 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRNP40 Protein Structure

WD40

WD40: WD domain, G-beta repeat (61 - 94)

WD40

WD40: WD domain, G-beta repeat (103 - 137)

WD40

WD40: WD domain, G-beta repeat (142 - 180)

WD40

WD40: WD domain, G-beta repeat (193 - 221)

WD40

WD40: WD domain, G-beta repeat (226 - 263)

WD40

WD40: WD domain, G-beta repeat (291 - 313)

WD40

WD40: WD domain, G-beta repeat (320 - 351)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
Protein Preferred Names Protein Names

U5 small nuclear ribonucleoprotein 40 kDa protein

  • 38 kDa-splicing factor

SNRNP40 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SNRNP40 Q96DI7 SNRNP200 Homo sapiens O75643
Anti Tag CoIP
33961781
Intra
SNRNP40 Q96DI7 SNRNP200 Homo sapiens O75643
Anti Tag CoIP
28514442
Intra
SNRNP40 Q96DI7 SNRNP200 Homo sapiens O75643
Anti Tag CoIP
35271311
Intra
SNRNP40 Q96DI7 SNRNP200 Homo sapiens O75643
Anti Bait CoIP
17353931
Intra
SNRNP40 Q96DI7 EFTUD2 Homo sapiens Q15029
Anti Tag CoIP
28514442
Intra
SNRNP40 Q96DI7 EFTUD2 Homo sapiens Q15029
Anti Tag CoIP
35271311
Intra
SNRNP40 Q96DI7 EFTUD2 Homo sapiens Q15029
Anti Bait CoIP
17353931
Intra
SNRNP40 Q96DI7 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
SNRNP40 Q96DI7 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
SNRNP40 Q96DI7 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Anti Bait CoIP
9774689
Intra
SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
33961781
Intra
SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Far-WB
9774689
Intra
SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
28514442
Intra
SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Anti Tag CoIP
35271311
Intra
SNRNP40 Q96DI7 PRPF8 Homo sapiens Q6P2Q9
Anti Bait CoIP
17353931
Intra
SNRNP40 Q96DI7 DDX23 Homo sapiens Q9BUQ8
Anti Tag CoIP
35271311
Intra
SNRNP40 Q96DI7 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
SNRNP40 Q96DI7 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
SNRNP40 Q96DI7 GFAP Homo sapiens P14136
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Burn-Mckeown Syndrome

  • Choanal Atresia-Hearing Loss-Cardiac Defects-Craniofacial Dysmorphism Syndrome

  • Oculootofacial Dysplasia

  • BMKS

  • Oofd

  • Bilateral Choanal Atresia, Cardiac Defects, Deafness, And Dysmorphic Appearance

  • Choanal Atresia - Deafness - Cardiac Defects - Dysmorphism Syndrome

  • Choanal Atresia Deafness Cardiac Defects Dysmorphism

  • Oculo-Oto-Facial Dysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS13498 SNRNP40 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SNRNP40 MGD MGI:1913835
Felis catus SNRNP40 VGNC VGNC:65534
Bos taurus SNRNP40 VGNC VGNC:35071
Rattus norvegicus SNRNP40 RGD RGD:1309198
Macaca mulatta SNRNP40 VGNC VGNC:100144
Canis familiaris SNRNP40 VGNC VGNC:46607
Others SNRNP40 NCBI