HDAC6/HSP90-IN-2
HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor of HDAC6 and Hsp90, with IC50s of 105.7 and 61 nM, respectively. HDAC6/HSP90-IN-2 can be used for the research of cancer.
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- CAS. Nr.: 2803866-22-8
- Formel: C19H22N2O5
- Molecular Weight:358.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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HDAC6 106 nM (IC50) |
HDAC1 654.5 nM (IC50) |
HDAC3 1539 nM (IC50) |
HDAC7 1691 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| NCI-H1975 | GI50 |
1.7 μM
Compound: 6e
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Antiproliferative activity against human NCI-H1975 cells assessed as growth inhibition incubated upto 72 hrs by CellTiter96 Aqueous One Solution Cell Proliferation assay
Antiproliferative activity against human NCI-H1975 cells assessed as growth inhibition incubated upto 72 hrs by CellTiter96 Aqueous One Solution Cell Proliferation assay
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[PMID: 35834905] |
HDAC6/HSP90-IN-2 (compound 6e) (0.05-2 μM; 24 h) effects HSP90, HDAC6 and signaling pathways regulated by Hsp90 dose-dependently[1]. HDAC6/HSP90-IN-2 (compound 6e) (2 μM; 24 h) promotes the acetylation of HSP90[1]. HDAC6/HSP90-IN-2 (compound 6e) (0-100 μM; 24-72 h) inhibits the growth of H1975 non-small cell lung cancer cells[1]. HDAC6/HSP90-IN-2 (compound 6e) (0-2 μM; 24 h) induces apoptosis of H1975 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H1975 cells
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Concentration:0.05, 0.1, 0.5, 1 and 2 μM
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Incubation Time:24 hours
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Result:Showed inhibitory effect to Hsp90 and HDACs dose-dependently and increased the expression levels of Hsp70 and Hsp90 probably by activates HSF1.
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Cell Line:H1975 cells
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Concentration:2 μM
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Incubation Time:24 hours
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Result:Promoted the acetylation of Hsp90 by inhibiting HDAC6, and increased the acetylation at K294 residue of Hsp90.
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Cell Line:H1975 cells
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Concentration:0, 0.5, 1 and 2 μM
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Incubation Time:24 hours
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Result:Induced early and late apoptosis of H1975 cells dose-dependently.
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Cell Line:H1975 cells
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Concentration:0-100 μM
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Incubation Time:24, 48 and 72 h
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Result:Inhibited the growth of H1975 non-small cell lung cancer cells with a GI50 value of 1.7 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD-scid IL2Rgammanull (NSG) mouse with H1975 cells xenograft[1]
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Dosage:25-50 mg/kg
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Administration:Intraperitoneal injection; 25-50 mg/kg for every weekdays; for 6 weeks
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Result:Delayed tumor growth after 2 weeks and reduced the growth rates of tumors in mice.
Chemical Information
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CAS. Nr. 2803866-22-8
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Molecular Weight 358.39
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Formel C19H22N2O5
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SMILES
OC1=C(C(C)C)C=C(C(N(C)CC2=CC=C(C=C2)C(NO)=O)=O)C(O)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC6/HSP90-IN-2 Related Classifications
HY-150774 Related Classifications
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