Iprindole hydrochloride
Iprindole hydrochloride, an opioid receptor agonist, is a tricyclic antidepressant. Iprindole hydrochloride shortens the immobility time in mice forced swimming test, which can be reversed by the opiate antagonist Naloxone (HY-17417A). Iprindole hydrochloride induces lamellar body formation but devoid of lamellar bodies. Iprindole hydrochloride can be used for the research of depression.
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- CAS. Nr.: 20432-64-8
- Formel: C19H29ClN2
- Molecular Weight:320.90
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
Iprindole (0.1-10 μM; 8 h) hydrochloride induces the formation of lamellar bodies in L-2 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Iprindole (10-50 mg/kg; i.p.; single dose) hydrochloride shortens the immobility time in male ICR Swiss mice forced swimming test[2].
Iprindole hydrochloride's (20 mg/kg; i.p.; single dose) activity is reserved by the opiate antagonist Naloxone in male ICR Swiss mice forced swimming test[2].
Iprindole hydrochloride's (10 mg/kg; i.p.; single dose) activity is enhanced by inhibitor of its degradation Bestatin (HY-B0134) or Thiorphan (HY-W013375)) in male ICR Swiss mice forced swimming test[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Domestic cats[1]
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Dosage:1.0 mg/kg; 2.0 mg/kg; 5.0 mg/kg; 20 mg/kg; 40 mg/kg
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Administration:i.p.; single dose
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Result:Did not significantly reduce REM sleep compared to population standards.
Did not significantly affect NREM sleep, wakefulness, or indeterminate periods.
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Animal Model:ICR Swiss mice (male, 20-25 g, forced swimming test)[2]
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Dosage:10 mg/kg; 20 mg/kg; 50 mg/kg
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Administration:i.p.; single dose
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Result:Shortened the immobility time.
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Animal Model:ICR Swiss mice (male, 20-25 g, forced swimming test)[2]
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Dosage:20 mg/kg plus Naloxone (1 mg/kg)
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Administration:i.p.; single dose
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Result:Activity was reserved by the opiate antagonist Naloxone.
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Animal Model:ICR Swiss mice (male, 20-25 g, forced swimming test)[2]
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Dosage:10 mg/kg plus Bestatin or
Thiorphan(10 μg/kg) -
Administration:i.p.; single dose
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Result:Further decreased the immobility time.
Chemical Information
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CAS. Nr. 20432-64-8
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Molecular Weight 320.90
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Formel C19H29ClN2
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SMILES
CN(C)CCCN1C(CCCCCC2)=C2C3=C1C=CC=C3.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Baxter BL, et al. Iprindole: an antidepressant which does not block REM sleep. Nature. 1969 Aug 16;223(5207):750-2. [Content Brief]
[2]. de Felipe MC, et al. Antidepressant action of imipramine and iprindole in mice is enhanced by inhibitors of enkephalin-degrading peptidases. Eur J Pharmacol. 1989 Jan 10;159(2):175-80. [Content Brief]
[3]. Martin WJ 2nd, et al. Iprindole reverses the lamellar body deficiency of cultured L-2 cells. Possible implications in the reversal of surfactant deficiency. Am J Pathol. 1987 Oct;129(1):34-43. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Iprindole hydrochloride Related Classifications
HY-12392A Related Classifications
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