Solasodine hydrochloride
Based on 6 publication(s) in Google Scholar
Solasodine (Purapuridine) hydrochloride is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine hydrochloride induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine hydrochloride has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities.
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- CAS. Nr.: 6106-33-8
- Formel: C27H44ClNO2
- Molecular Weight:450.10
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Solasodine hydrochloride
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Beschreibung
In Vitro
Solasodine (90 μM; 2 days) hydrochloride treatment displays significant sprouting in P19 cells. Solasodine hydrochloride induces strong expression of the different neuronal markers studied, including βIII-tubulin, synaptophysin, MAP2, ChAT, and neuroblast marker doublecortin. Solasodine hydrochloride induces the differentiation of P19 cells, essentially towards the neuronal pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Solasodine (375 μM; i.c.v.; for 2 weeks) hydrochloride treatment results a significant increase in bromodeoxyuridine uptake by cells of the ependymal layer, subventricular zone, and cortex that co-localized with doublecortin immunostaining. Solasodine hydrochloride treatment in rats results in a dramatic increase in expression of the cholesterol- and drug-binding translocator protein in ependymal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss albino mice (18-25 g) treated with Picrotoxin (PCT) or Thiopental[2]
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Dosage:25 mg/kg, 50 mg/kg and 100 mg/kg
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Administration:Intraperitoneal injection; once
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Result:Significantly delayed latency of hind limb tonic extensor (HLTE) phase in the PCT-induced convulsions. And significantly potentiated Thiopental-provoked sleep in a dose-dependent manner.
Chemical Information
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CAS. Nr. 6106-33-8
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Molecular Weight 450.10
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Formel C27H44ClNO2
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SMILES
C[C@H](CC1)CN[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C.Cl
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Synonyms
Purapuridine hydrochloride; Solancarpidine hydrochloride; Solasodin hydrochloride
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (6)
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Journal Impact Factor
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Most Recent
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PLoS Biol
2024 Jun 27;22(6):e3002672. PMID: 38935621 -
J Cell Mol Med
Solasodine, a Natural Steroidal Alkaloid, Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption: A Study Based on Network Pharmacology and Experimental Validation. [Abstract]2026 Jun;30(12):e71253. PMID: 42322165 -
Toxicol Appl Pharmacol
Solasodine binds to glucocorticoid receptor to ameliorate airway remodeling and excessive autophagy in bronchial smooth muscle cells for allergic asthma. [Abstract]2025 May:498:117313. PMID: 40154577
Solasodine hydrochloride purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 May:498:117313. [Abstract]
HBSMCs were treated with a series of Solasodine (10, 20, 40, 80, 100 μM) for 24 h, and the cell viability was measured by CCK-8.
Solasodine hydrochloride purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 May:498:117313. [Abstract]
Levels of GR and α-SMA proteins were measured by western blotting treated with Solasodine (40 μM).
Solasodine hydrochloride purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 May:498:117313. [Abstract]
Levels of FOXO3A expression were measured by immunofluorescence treated with Solasodine (40 μM).
Solasodine hydrochloride purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 May:498:117313. [Abstract]
Levels of IL-4 and IL-13 in bronchoalveolar lavage fluids (BLAFs) were analyzed using their corresponding ELISA kits treated with Solasodine (10 mg/kg, p.o.).
Solasodine hydrochloride purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2025 May:498:117313. [Abstract]
The α-SMA expression expression were analyzed by immunohistochemistry treated with Solasodine (10 mg/kg, p.o.).
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Drug Res (Stuttg)
Co-Adjuvancy of Solasodine & CoQ10 Against High Fat Diet-Induced Insulin Resistance Rats Via Modulating IRS-I and PPAR-γ Proteins Expression. [Abstract]2022 Jul;72(6):327-335. PMID: 35724671 -
bioRxiv
An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]2024 Apr 3:2023.06.02.542933. PMID: 37333363
Reinheit & Dokumentation
Verweise
[1]. Lecanu L, et al. The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo. Neuroscience. 2011 Jun 2;183:251-64. [Content Brief]
[2]. Akhtar S, et al. Evaluation and Elucidation Studies of Natural Aglycones for Anticancer Potential using Apoptosis-Related Markers: An In silico Study. Interdiscip Sci. 2018 Jun;10(2):297-310. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Solasodine hydrochloride Related Classifications
HY-W751400 Related Classifications
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