SU-11752
SU-11752 is an inhibitor for DNA-dependent protein kinase (DNA-PK) with an IC50 of 0.13 μM. SU-11752 inhibits PI3K p110γ kinase with IC50 of 1.1 μM. SU-11752 binds competitively for ATP-site in DNA-PK, results in inhibition of intracellular DNA double-strand break repair and increases the sensitivity of cells to radiotherapy.
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- CAS. Nr.: 688036-19-3
- Formel: C26H27N3O5S
- Molecular Weight:493.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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DNA-PK 0.13 μM (IC50) |
p110γ 1.1 μM (IC50) |
Chemical Information
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CAS. Nr. 688036-19-3
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Molecular Weight 493.57
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Formel C26H27N3O5S
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SMILES
O=C(CCC1=C(NC(/C=C2C(NC3=C\2C=C(C=C3)S(=O)(NC4=CC=CC=C4)=O)=O)=C1CC)CC)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SU-11752 Related Classifications
HY-114923 Related Classifications
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