Calreticulin-3

Definition:

During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.

References:

[1]. Ryuji Nomura, et al. Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2+ -binding protein. Histochem Cell Biol. 2011 Jun;135(6):531-8. [Content Brief]

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