Cyclin-L1

Definition:

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC).

References:

[1]. Liliane A Dickinson, et al. Cyclin L is an RS domain protein involved in pre-mRNA splicing. J Biol Chem. 2002 Jul 12;277(28):25465-73. [Content Brief]

[2]. C Sticht, et al. Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC). Br J Cancer. 2005 Feb 28;92(4):770-4. [Content Brief]

[3]. Richard Redon, et al. Amplicon mapping and transcriptional analysis pinpoint cyclin L as a candidate oncogene in head and neck cancer. Cancer Res. 2002 Nov 1;62(21):6211-7. [Content Brief]

[4]. Pascal Loyer, et al. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J Biol Chem. 2008 Mar 21;283(12):7721-32. [Content Brief]

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