Eppin
Definition:
Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.
References:
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[1]. Zengjun Wang, et al. Eppin: a molecular strategy for male contraception. Soc Reprod Fertil Suppl. 2007;65:535-42. [Content Brief]
[2]. Suresh Yenugu, et al. Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif. Biol Reprod. 2004 Nov;71(5):1484-90. [Content Brief]
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