Inactive rhomboid protein 1

Definition:

Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

References:

[1]. Markus Zettl, et al. Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. Cell. 2011 Apr 1;145(1):79-91. [Content Brief]

[2]. Takatoshi Nakagawa, et al. Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands. Dev Dyn. 2005 Aug;233(4):1315-31. [Content Brief]

[3]. Zhenwen Yan, et al. Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth. Mol Cancer Ther. 2008 Jun;7(6):1355-64. [Content Brief]

[4]. Huafei Zou, et al. Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells. FASEB J. 2009 Feb;23(2):425-32. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.