Insulin receptor-related protein

Definition:

Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

References:

[1]. Igor E Deyev, et al. Insulin receptor-related receptor as an extracellular alkali sensor. Cell Metab. 2011 Jun 8;13(6):679-89. [Content Brief]

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