Intermembrane lipid transfer protein VPS13D
Definition:
Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission. Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis.
Verweise:
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[1]. Eunju Seong, et al. Mutations in VPS13D lead to a new recessive ataxia with spasticity and mitochondrial defects. Ann Neurol. 2018 Jun;83(6):1075-1088. [Content Brief]
[2]. Allyson L Anding, et al. Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Curr Biol. 2018 Jan 22;28(2):287-295.e6. [Content Brief]
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