PC-3
Definition:
PC-3 is a human epithelial prostate carcinoma cell line established from a poorly differentiated prostatic adenocarcinoma metastatic to bone and exhibits epithelial, poorly differentiated morphology[1]. The cells are aneuploid, grow without anchorage, form tumors in nude mice, show reduced serum dependence, and do not respond to androgens, glucocorticoids, epidermal growth factor, or fibroblast growth factor[1]. PC-3 has been used to model androgen-independent prostate cancer, examine apoptosis and cell-cycle responses to candidate compounds, and study osteolytic interactions after intratibial implantation, including pathways involving osteoprotegerin, RANK ligand, parathyroid hormone-related protein, and endothelin-1[2][3].
References:
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[1]. Kaighn ME et al. Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Invest Urol. 1979;17(1):16-23. [Content Brief]
[3]. Zhang P et al. Matrine inhibits proliferation and induces apoptosis of the androgen‑independent prostate cancer cell line PC-3. Mol Med Rep. 2012;5(3):783-7. [Content Brief]
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