Repressor LexA
Definition:
EC Tree > 3 Hydrolases > 3.4 Acting on peptide bonds (peptidases) > 3.4.21 Serine endopeptidases > 3.4.21.88 Repressor LexA
Repressor LexA is a bacterial SOS-response autopeptidase and the type example of peptidase family S24, whose repressor activity requires RecA and single-stranded DNA and which uses a Ser/Lys catalytic dyad; LexA represses the SOS regulon controlling DNA-repair genes, and in the presence of ssDNA RecA interacts with LexA causing autocatalytic cleavage at the Ala84-Gly bond that disrupts the DNA-binding domain and inactivates the repressor, derepressing the SOS DNA-repair response (this peptidase activity was previously attributed to RecA). By self-cleaving it enables the bacterial DNA-damage response. It appears in viruses and cellular organisms.
Repressor LexA is a bacterial SOS-response autopeptidase and the type example of peptidase family S24, whose repressor activity requires RecA and single-stranded DNA and which uses a Ser/Lys catalytic dyad; LexA represses the SOS regulon controlling DNA-repair genes, and in the presence of ssDNA RecA interacts with LexA causing autocatalytic cleavage at the Ala84-Gly bond that disrupts the DNA-binding domain and inactivates the repressor, derepressing the SOS DNA-repair response (this peptidase activity was previously attributed to RecA). By self-cleaving it enables the bacterial DNA-damage response. It appears in viruses and cellular organisms.
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