Separin

Definition:

Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.

References:

[1]. S Hauf, et al. Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. Science. 2001 Aug 17;293(5533):1320-3. [Content Brief]

[2]. H Zou, et al. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science. 1999 Jul 16;285(5426):418-22. [Content Brief]

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