Sulfhydryl oxidase 1

Definition:

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.

References:

[1]. Assaf Alon, et al. The dynamic disulphide relay of quiescin sulphydryl oxidase. Nature. 2012 Aug 16;488(7411):414-8. [Content Brief]

[2]. Tal Ilani, et al. A secreted disulfide catalyst controls extracellular matrix composition and function. Science. 2013 Jul 5;341(6141):74-6. [Content Brief]

[3]. Erin J Heckler, et al. Human quiescin-sulfhydryl oxidase, QSOX1: probing internal redox steps by mutagenesis. Biochemistry. 2008 Apr 29;47(17):4955-63. [Content Brief]

[4]. Seema Chakravarthi, et al. Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1. Biochem J. 2007 Jun 15;404(3):403-11. [Content Brief]

[5]. Iris Grossman, et al. An inhibitory antibody blocks the first step in the dithiol/disulfide relay mechanism of the enzyme QSOX1. J Mol Biol. 2013 Nov 15;425(22):4366-78. [Content Brief]

[6]. Gabriel Javitt, et al. cis-Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures. Protein Sci. 2019 Jan;28(1):228-238. [Content Brief]

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