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Synemin

Definition:

Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.

References:

[1]. Ning Sun, et al. Human alpha-synemin interacts directly with vinculin and metavinculin. Biochem J. 2008 Feb 1;409(3):657-67. [Content Brief]

[2]. Rahul C Bhosle, et al. Interactions of intermediate filament protein synemin with dystrophin and utrophin. Biochem Biophys Res Commun. 2006 Aug 4;346(3):768-77. [Content Brief]

[3]. Y Mizuno, et al. Desmuslin, an intermediate filament protein that interacts with alpha -dystrobrevin and desmin. Proc Natl Acad Sci U S A. 2001 May 22;98(11):6156-61. [Content Brief]

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