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Testin

Definition:

Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.

References:

[1]. Amanda S Coutts, et al. TES is a novel focal adhesion protein with a role in cell spreading. J Cell Sci. 2003 Mar 1;116(Pt 5):897-906. [Content Brief]

[2]. Boyan K Garvalov, et al. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J Cell Biol. 2003 Apr 14;161(1):33-9. [Content Brief]

[3]. E S Tobias, et al. The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. Oncogene. 2001 May 17;20(22):2844-53. [Content Brief]

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