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Tomoregulin-2

Definition:

May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.

References:

[1]. Nazim Ali, et al. Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17. J Biol Chem. 2007 Dec 28;282(52):37378-88. [Content Brief]

[2]. M Horie, et al. Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons. Genomics. 2000 Jul 15;67(2):146-52. [Content Brief]

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