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U2OS

Definition:

U2OS is a human cancer cell line derived from Bone, tibia and associated with Osteosarcoma. Its continuous tumor-cell growth supports reproducible mechanistic and pharmacological experiments. U2OS is used as an in vitro model of Osteosarcoma to investigate p53 signaling, Notch signaling, apoptosis, cell proliferation, cell migration, and cell invasion.

References:

[1]. Lee HK, Park SH, Nam MJ. Proteasome inhibitor MG132 induces apoptosis in human osteosarcoma U2OS cells. Human & experimental toxicology. 2021;40(11):1985-1997. [Content Brief]

[2]. Xu H, et al. [Panax notoginseng saponins inhibit proliferation, migration, invasion and promote apoptosis of U2OS osteosarcoma cells via blocking Notch1 pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2021;37(8):716-721.

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