Ubiquitin-Proteasome Pathway (UPP)

Definition:

Ubiquitin-Proteasome Pathway (UPP) is a major intracellular protein degradation pathway. Ub is conjugated to proteins that are destined for degradation by an ATP-dependent process.

References:

[1]. Lecker SH, et al. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol. 2006 Jul;17(7):1807-19. [Content Brief]

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