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Cat. No.: HY-FLB0372A

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Bromhexine hydrochloride solution

Bromhexine hydrochloride solution is mainly composed of Bromhexine hydrochloride (HY-B0372A). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC₅₀ of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions.

For research use only. We do not sell to patients.

CAS No.: 611-75-6
Formula: C₁₄H₂₁Br₂ClN₂
Molecular Weight:412.59

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Bromhexine hydrochloride solution Chemical Structure

CAS No.: 611-75-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

All HIV Isoforms :

Chemical Information

CAS No. 611-75-6
Molecular Weight 412.59
Formula C₁₄H₂₁Br₂ClN₂
SMILES

CN(C1CCCCC1)CC2=CC(Br)=CC(Br)=C2N.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jared M Lucas, et al. The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov. 2014 Nov;4(11):1310-25. [Content Brief]

[2]. Li Wen Shen, et al. TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections. Biochimie. 2017 Nov;142:1-10. [Content Brief]

[3]. Roberto Maggio, et al. Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection. Pharmacol Res. 2020 Jul;157:104837. [Content Brief]

[4]. Santosh Chauhan, et al. Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential. Nat Commun. 2015 Oct 27;6:8620. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Bromhexine hydrochloride solution

All HIV Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bromhexine hydrochloride solution Related Classifications

HY-FLB0372A Related Classifications

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Keywords

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