CH25H - cholesterol 25-hydroxylase Gene

Also Known as C25H

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9023

About CH25H

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,205,629-89,207,317 (from NCBI)

This gene has 1 transcript (splice variant), 210 orthologues and 3 paralogues.

Summary

This is an intronless gene that is involved in Cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most Other sterol hydroxylases, this enzyme is a member of a small family of Enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. [provided by RefSeq, Jul 2008]

CH25H Products (1)

mRNA Protein Name
NM_003956.4 NP_003947.1 cholesterol 25-hydroxylase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cholesterol 25-hydroxylase activity IDA
IDA: Inferred from direct assay
32944968 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cholesterol metabolic process IDA
IDA: Inferred from direct assay
33239446 GOA
involved in negative regulation of fusion of virus membrane with host plasma membrane IDA
IDA: Inferred from direct assay
32944968 GOA
involved in response to type I interferon IDA
IDA: Inferred from direct assay
33239446 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CH25H Protein Structure

FA_hydroxylase

FA_hydroxylase: Fatty acid hydroxylase superfamily (129 - 244)

  • 0
  • 100
  • 200
  • 272 a.a.
Protein Preferred Names Protein Names

cholesterol 25-hydroxylase

  • cholesterol 25-monooxygenase

CH25H Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CH25H O95992 KRTAP12-4 Homo sapiens P60329
Validated Y2H
32296183
Intra
CH25H O95992 OTX1 Homo sapiens P32242
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lysosomal Acid Lipase Deficiency

  • Wolman Disease

  • Cholesteryl Ester Storage Disease

  • Lal Deficiency

  • Lipa Deficiency

  • Cholesterol Ester Storage Disease

  • CESD

  • Cholesterol Ester Hydrolase Deficiency

  • Acid Lipase Deficiency

  • Acid Esterase Deficiency

  • Familial Xanthomatosis

  • Wolman Xanthomatosis

  • Wolman'S Disease

  • Wolman'S Or Triglyceride Storage Type Iii Disease

  • Xanthomatosis, Familial

  • Liposomal Acid Lipase Deficiency, Wolman Type

  • Familial Visceral Xanthomatosis

  • Primary Familial Xanthomatosis

  • Primary Familial Xanthomatosis With Adrenal Calcification

  • Acid Lipase Disease

  • WOD

  • Acid Cholesteryl Ester Hydrolase Deficiency, Type 2
Lysosomal And Lipase Deficiency
Cerebrotendinous Xanthomatosis

  • CTX

  • Cerebral Cholesterinosis

  • Cholestanol Storage Disease

  • Xanthomatosis, Cerebrotendinous

  • Sterol 27-Hydroxylase Deficiency

  • Xanthomatosis Cerebrotendinous

  • Cerebrotendinous Cholesterinosis

  • Cholestanolosis

  • Van Bogaert-Scherer-Epstein Disease
Cholesterol Ester Storage Disease
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17906 Ch25h Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02589 CH25H Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24375 Ch25h Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CH25H VGNC VGNC:106022
Rattus norvegicus CH25H RGD RGD:1310575
Mus musculus CH25H MGD MGI:1333869
Canis familiaris CH25H VGNC VGNC:52926
Bos taurus CH25H VGNC VGNC:27261
Others CH25H NCBI