RAYZ-8009
RAYZ-8009 is a DOTA (HY-W053583)-modified macrocyclic peptide with high affinity for GPC3. The radiolabeled form of RAYZ-8009, [68Ga]Ga-RAYZ-8009, is used for PET imaging studies of hepatocellular carcinoma.
For research use only. We do not sell to patients.
- CAS No.: 3066113-06-9
- Formula: C91H119N17O22S
- Molecular Weight:1835.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
RDC Peptide |
In Vitro
RAYZ-8009 shows high binding affinity for mouse, canine, and cynomolgus monkey GPC3 proteins, and exhibits potent cell binding and efficient internalization in GPC3-positive HepG2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3066113-06-9
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Molecular Weight 1835.08
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Formula C91H119N17O22S
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SMILES
CN(C([C@@H](NC([C@](NC([C@](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@](N(C([C@@H](N(C(CSC[C@H](N(C([C@@H](NC(CNC1=O)=O)CC2=CN=C(C3=CC=CC=C3)C=C2)=O)C)C(N)=O)=O)C)CCCCN)=O)C)([H])[C@@H](C)CC)=O)CC(O)=O)=O)C)CCC(N)=O)=O)CC4=CC=C(C=C4)C(O)=O)=O)([H])[C@@H](C)OC)=O)([H])[C@@H](C)CC)=O)CC5=CC=C(C=C5)OCC(O)=O)=O)[C@H]1CC6=CC7=C(C=CN=C7)C=C6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RAYZ-8009 Related Classifications
HY-P12340 Related Classifications
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