3066113-06-9
Chemical Structure
RAYZ-8009
- CAS No.: 3066113-06-9
- Formula:C91H119N17O22S
- Molecular Weight:1835.08
InChIKey: YSLGOOUKCWCKAQ-VLZIFVTISA-N
SMILES: CN(C([C@@H](NC([C@](NC([C@](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@](N(C([C@@H](N(C(CSC[C@H](N(C([C@@H](NC(CNC1=O)=O)CC2=CN=C(C3=CC=CC=C3)C=C2)=O)C)C(N)=O)=O)C)CCCCN)=O)C)([H])[C@@H](C)CC)=O)CC(O)=O)=O)C)CCC(N)=O)=O)CC4=CC=C(C=C4)C(O)=O)=O)([H])[C@@H](C)OC)=O)([H])[C@@H](C)CC)=O)CC5=CC=C(C=C5)OCC(O)=O)=O)[C@H]1CC6=CC7=C(C=CN=C7)C=C6
Biological Activity: RAYZ-8009 is a DOTA (HY-W053583)-modified macrocyclic peptide with high affinity for GPC3. The radiolabeled form of RAYZ-8009, [68Ga]Ga-RAYZ-8009, is used for PET imaging studies of hepatocellular carcinoma[1][2].
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RAYZ-8009 | RAYZ-8009 is a DOTA (HY-W053583)-modified macrocyclic peptide with high affinity for GPC3. The radiolabeled form of RAYZ-8009, [68Ga]Ga-RAYZ-8009, is used for PET imaging studies of hepatocellular carcinoma. | |||||||||||||||||||||
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References
- [1]. Viering O, et al. Biodistribution and Radiation Dosimetry of [Ga]Ga-RAYZ-8009, a Glypican 3-Targeting Compound for Imaging of Hepatocellular Carcinoma. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2025 Nov 03;66(11):1737-1742.
- [2]. Poot AJ, et al. [Ga]Ga-RAYZ-8009: A Glypican-3-Targeted Diagnostic Radiopharmaceutical for Hepatocellular Carcinoma Molecular Imaging-A First-in-Human Case Series. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2024 Oct 01;65(10):1597-1603.
