Δ4-Dafachronic acid
Based on 1 Customer Validation
Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology.
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- Pureté: 96.93%
- CAS No.: 23017-97-2
- Formule: C27H42O3
- Masse moléculaire:414.62
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Δ4-Dafachronic acid (0.3 mM) is the preferred substrate for the SDENChol_v1_11189 ACS enzyme[2].
Δ4-dafachronic acid (2.3 μM; 3-6 days) promotes molting of Haemonchus contortus L3 to L4 in cell-free in vitro culture[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Austrofundulus limnaeus embryos[1]
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Dosage:25 μM; 50 μM; 75 μM
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Administration:immersion in embryo media; daily media change
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Result:Induced ~15% of embryos to follow escape trajectory and ~85% to enter diapause at 25 μM.
Induced ~40% of embryos to follow escape trajectory and ~60% to enter diapause at 50 μM.
Induced ~90% of embryos to follow escape trajectory and ~10% to enter diapause at 75 μM.
Produced escape embryos with developmental rate and pattern indistinguishable from normal escape embryos.
Resulted in delayed development for embryos that entered diapause despite treatment.
Chemical Information
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CAS No. 23017-97-2
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Appearance Solid
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Masse moléculaire 414.62
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Formule C27H42O3
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Color White to off-white
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SMILES
CC(C(O)=O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : ≥ 2.5 mg/mL (6.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Romney ALT, et al. Temperature-dependent vitamin D signaling regulates developmental trajectory associated with diapause in an annual killifish. Proc Natl Acad Sci U S A. 2018;115(50):12763-12768. [Content Brief]
[2]. Warnke M, et al. Functional Characterization of Three Specific Acyl-Coenzyme A Synthetases Involved in Anaerobic Cholesterol Degradation in Sterolibacterium denitrificans Chol1S. Appl Environ Microbiol. 2018;84(7):e02721-17. Published 2018 Mar 19. [Content Brief]
[3]. Niciura SCM, et al. In vitro culture of parasitic stages of Haemonchus contortus. Rev Bras Parasitol Vet. 2023;32(1):e010122. Published 2023 Jan 13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4118 mL | 12.0592 mL | 24.1185 mL | 60.2962 mL |
| 5 mM | 0.4824 mL | 2.4118 mL | 4.8237 mL | 12.0592 mL |
Δ4-Dafachronic acid Related Classifications
HY-131492 Related Classifications
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- Δ4-Dafachronic acid
- 23017-97-2
- Endogenous Metabolite
- VD/VDR
- Sterolibacterium denitrificans Chol1S
- Haemonchus contortus L4
- acyl-coenzyme A synthetase
- Haemonchus contortus L3
- Austrofundulus limnaeus embryos
- vitamin D receptor
- Haemonchus contortus
- anaerobic cholesterol degradation pathway
- Inhibitor
- inhibitor
- inhibit