23017-97-2
Chemical Structure
Δ4-Dafachronic acid
- CAS No.: 23017-97-2
- Formula:C27H42O3
- Molecular Weight:414.62
IUPAC Name: (6R)-6-((8S,9S,10R,13R,14S,17R)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylheptanoic acid
InChIKey: PSXQJZDFWDKBIP-NNWQCNCGSA-N
SMILES: CC(C(O)=O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
Biological Activity: Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology[1][2][3].
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Δ4-Dafachronic acid | 96.93% | Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology. | ||||||||||||||||||||
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Δ4-Dafachronic Acid-d3 | Δ4-Dafachronic Acid-d3 is deuterium labeled Δ4-Dafachronic acid (HY-131492). Δ4‑Dafachronic acid is an endogenous steroid hormone, an agonist of the DAF‑12 nuclear receptor, and a key ligand for the vitamin D receptor (VDR). Δ4‑Dafachronic acid promotes the active escape developmental trajectory in Austrofundulus limnaeus embryos even under diapause‑inducing conditions. Δ4‑Dafachronic acid is suitable for research on the developmental biology. | |||||||||||||||||||||
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- [1]. Romney ALT, et al. Temperature-dependent vitamin D signaling regulates developmental trajectory associated with diapause in an annual killifish. Proc Natl Acad Sci U S A. 2018;115(50):12763-12768. [Content Brief]
- [2]. Warnke M, et al. Functional Characterization of Three Specific Acyl-Coenzyme A Synthetases Involved in Anaerobic Cholesterol Degradation in Sterolibacterium denitrificans Chol1S. Appl Environ Microbiol. 2018;84(7):e02721-17. Published 2018 Mar 19. [Content Brief]
- [3]. Niciura SCM, et al. In vitro culture of parasitic stages of Haemonchus contortus. Rev Bras Parasitol Vet. 2023;32(1):e010122. Published 2023 Jan 13. [Content Brief]
