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Cat. No.: HY-12499

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(S)-Willardiine

(Synonyms: (-)-Willardiine)

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(S)-Willardiine ((-)-Willardiine) is a subtype-selective glutamate receptor agonist and the active isomer of Willardiine. Willardiine binds to and activates hGluR1, hGluR2, hGluR4 and hGluR5, with K_i values of 3.6 nM and 0.24 nM for hGluR4 and hGluR5, respectively. (S)-Willardiine is used to investigate the distribution and physiological functions of glutamate receptor subunits in the central nervous system.

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Pureté: 98.93%
CAS No.: 21416-43-3
Formule: C₇H₉N₃O₄
Masse moléculaire:199.17

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

(S)-Willardiine Chemical Structure

CAS No.: 21416-43-3

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

AMPA Receptor

Kainate Receptor

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Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	EC₅₀	11.5 μM Compound: (S)-2a, (S)-willardiine	Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method Agonist activity at cyclothiazide-desensitized rat recombinant flop iGluR1 expressed in Xenopus laevis oocytes by two electrode voltage-clamp electrophysiology method	[PMID: 18811139]

In Vitro

(S)-Willardiine (10^-12-10^-3 M; 60 min) binds with low affinity to homomeric hGluR1, hGluR2, and hGluR4 receptors, displaying the weakest potency among tested willardiine analogs on these human AMPA receptor subtypes^[1].
(S)-Willardiine (10^-12-10^-3 M; 60 min) binds with very low affinity to homomeric hGluR5 receptors, displaying the weakest potency among tested willardiine analogs on this human kainate receptor subtype^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 21416-43-3
Appearance Solid
Masse moléculaire 199.17
Formule C₇H₉N₃O₄
Color White to off-white
SMILES

N[C@@H](CN(C(N1)=O)C=CC1=O)C(O)=O
Synonyms

(-)-Willardiine
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvant et solubilité

In Vitro:

H₂O : < 0.1 mg/mL (insoluble)

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Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
SDS (393 KB)
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- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jane DE, et al. Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. J Med Chem. 1997;40(22):3645-3650. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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(S)-Willardiine

MCE Bioactive Compound Library

Voir tous les produits spécifiques à Isoform iGluR