BRL-44408

BRL-44408 (5 mg/kg; i.p.; single administration) alleviates cecal ligation and puncture (CLP)-induced acute respiratory distress syndrome (ARDS) in rats by reducing pulmonary edema, pathological damage of lung tissues, macrophage infiltration, and proinflammatory mediator production, as well as inhibiting the activation of ERK1/2, p38MAPK and p65 signaling pathways^[1].
BRL-44408 (10 mg/kg; subcutaneous injection; single administration) significantly elevates extracellular norepinephrine (up to 204%), dopamine (up to 110%) and acetylcholine (up to 75%) levels in the medial prefrontal cortex (mPFC) of rats for at least 3.5 hours post-administration, without altering serotonin levels^[2].
BRL-44408 (3-30 mg/kg; i.p.; administered once at 24 h, 5 h and 1 h prior to testing, for a total of 3 times) exerts significant antidepressant-like effects in the forced swimming test in rats, reducing the immobility time by 30% (10 mg/kg) and 49% (30 mg/kg), while increasing the climbing time by 48% (10 mg/kg) and 107% (30 mg/kg)^[2].
BRL-44408 (10-30 mg/kg; i.p.; single administration; pretreated 20 minutes before testing) exerts significant antidepressant-like effects in the rat procedure-induced polydipsia test, reducing the additional water intake by 34% (17 mg/kg) and 44% (30 mg/kg), respectively^[2].
BRL-44408 (1-30 mg/kg; i.p.; single administration; pretreated 60 minutes prior to PPQ administration) exerts significant analgesic effects in a mouse PPQ visceral pain model, reversing somatic stretching behaviors by 32% (10 mg/kg) and 52% (30 mg/kg), respectively^[2].