Citronellol-d6
Citronellol-d6 is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis.
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- CAS No.: 220687-53-6
- Formule: C10H14D6O
- Masse moléculaire:162.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 220687-53-6
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Unlabeled CAS 106-22-9
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Masse moléculaire 162.30
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Formule C10H14D6O
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SMILES
[2H]C([2H])([2H])/C(C([2H])([2H])[2H])=C/CCC(C)CCO
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Synonyms
(±)-Citronellol-d6; (±)-β-Citronellol-d6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Yu WN, et al. Citronellol Induces Necroptosis of Human Lung Cancer Cells via TNF-α Pathway and Reactive Oxygen Species Accumulation. In Vivo. 2019 Jul-Aug;33(4):1193-1201 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Citronellol-d6 Related Classifications
HY-W010201S Related Classifications
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Keywords
- Citronellol-d6
- 220687-53-6
- (±)-Citronellol-d6
- (±)-β-Citronellol-d6
- Reactive Oxygen Species (ROS)
- Isotope-Labeled Compounds
- cardiotoxicity
- oxidative stress
- anticancer
- antibiotics
- antimicrobial
- neuroprotective
- anxiolytic
- antidepressant
- anti-stress
- hepatoprotective
- renal protective
- lung protective
- apoptosis
- Inhibitor
- inhibitor
- inhibit