(E) -4-Hydroxycrotonic acid
Based on 1 Customer Validation
(E)-4-Hydroxycrotonic acid (T-HCA) is a high-affinity ligand for GHB binding sites, with a ki value of 1.1 μM. The introduction of diaryl substituents into (E)-4-Hydroxycrotonic acid significantly enhances its affinity for GHB binding sites, with ki values ranging from 0.023 to 0.075 μM. (E)-4-Hydroxycrotonic acid holds promise for optimizing GHB ligand structures and assisting in the development of effective three-dimensional pharmacophore models.
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- Pureté: 98.0%
- CAS No.: 24587-49-3
- Formule: C4H6O3
- Masse moléculaire:102.09
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Chemical Information
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CAS No. 24587-49-3
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Appearance Solid
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Masse moléculaire 102.09
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Formule C4H6O3
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Color Light yellow to yellow
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SMILES
O=C(O)/C=C/CO
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Synonyms
trans-4-Hydroxycrotonic acid; trans-γ-Hydroxycrotonic acid; T‐HCA
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 175 mg/mL (1714.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (453 KB)
- English - EN (453 KB)
- Français - FR (453 KB)
- Deutsch - DE (453 KB)
- Norwegian - NO (453 KB)
- Español - ES (453 KB)
- Swedish - SV (453 KB)
- Italian - IT (453 KB)
- Korean - KR (453 KB)
- Portuguese - PT (453 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Krall J, et al. Molecular Hybridization of Potent and Selective γ-Hydroxybutyric Acid (GHB) Ligands: Design, Synthesis, Binding Studies, and Molecular Modeling of Novel 3-Hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-Hydroxycrotonic Acid (T-HCA) Analogs. J Med Chem. 2017 Nov 9;60(21):9022-9039. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 9.7953 mL | 48.9764 mL | 97.9528 mL | 244.8820 mL |
| 5 mM | 1.9591 mL | 9.7953 mL | 19.5906 mL | 48.9764 mL | |
| 10 mM | 0.9795 mL | 4.8976 mL | 9.7953 mL | 24.4882 mL | |
| 15 mM | 0.6530 mL | 3.2651 mL | 6.5302 mL | 16.3255 mL | |
| 20 mM | 0.4898 mL | 2.4488 mL | 4.8976 mL | 12.2441 mL | |
| 25 mM | 0.3918 mL | 1.9591 mL | 3.9181 mL | 9.7953 mL | |
| 30 mM | 0.3265 mL | 1.6325 mL | 3.2651 mL | 8.1627 mL | |
| 40 mM | 0.2449 mL | 1.2244 mL | 2.4488 mL | 6.1220 mL | |
| 50 mM | 0.1959 mL | 0.9795 mL | 1.9591 mL | 4.8976 mL | |
| 60 mM | 0.1633 mL | 0.8163 mL | 1.6325 mL | 4.0814 mL | |
| 80 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0610 mL | |
| 100 mM | 0.0980 mL | 0.4898 mL | 0.9795 mL | 2.4488 mL |
(E) -4-Hydroxycrotonic acid Related Classifications
HY-100982 Related Classifications
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