Tenm4 - teneurin transmembrane protein 4 Gene

Also Known as Doc4; ELM2; Odz4; l7Rn3; Ten-m4; l(7)-3Rn; mKIAA1302

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23966

Summary

Enables protein homodimerization activity. Involved in central nervous system myelin formation; positive regulation of gastrulation; and regulation of nervous system development. Acts upstream of or within cardiac cell fate specification; cardiac muscle cell proliferation; and gastrulation with mouth forming second. Located in cytoplasm; neuron projection; and nucleus. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch; central nervous system; forelimb bud; future brain; and somite. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to human TENM4 (teneurin transmembrane protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Tenm4 Products (3)

mRNA Protein Name
NM_001310760.1 NP_001297689.1 teneurin-4 isoform 1
NM_001310762.1 NP_001297691.1 teneurin-4 isoform 3
NM_011858.4 NP_035988.2 teneurin-4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
12000766 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
12000766 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within cardiac cell fate specification IMP
IMP: Inferred from mutant phenotype
17350578 MGI
acts upstream of or within cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17350578 MGI
involved in central nervous system myelin formation IMP
IMP: Inferred from mutant phenotype
22915103 MGI
acts upstream of or within gastrulation with mouth forming second IMP
IMP: Inferred from mutant phenotype
15489520 MGI
involved in positive regulation of gastrulation IMP
IMP: Inferred from mutant phenotype
15489520 MGI
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
22915103 MGI
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
22915103 MGI
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
35484136 MGI
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
22915103 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
35484136 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
22915103 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22915103 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9649432 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

teneurin-4

  • downstream of CHOP4

  • odd Oz/ten-m homolog 4

  • protein Odd Oz/ten-m homolog 4

  • ten-4

  • tenascin-M4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14365 TENM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22855 Tenm4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29369 Tenm4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tenm4 NCBI NCBI:26011