CHD6 - chromodomain helicase DNA binding protein 6 Gene

Also Known as CHD5; RIGB; CHD-6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84181

About CHD6

Cytogenetic location: 20q12 Genomic coordinates (GRCh38): 20:41,402,083-41,618,377 (from NCBI)

This gene has 8 transcripts (splice variants), 194 orthologues and 30 paralogues. Ubiquitous expression in ovary (RPKM 7.0), thyroid (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of Influenza Virus replication. [provided by RefSeq, Jul 2013]

CHD6 Products (1)

mRNA	Protein	Name
NM_032221.5	NP_115597.3	chromodomain-helicase-DNA-binding protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables ATP-dependent activity, acting on DNA	IDA IDA: Inferred from direct assay	17027977	GOA
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	16314513	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in cell redox homeostasis	IMP IMP: Inferred from mutant phenotype	16314513	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16314513	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in nucleoplasm	IDA IDA: Inferred from direct assay	17027977	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHD6 Protein Structure

Chromo

SNF2_N

Helicase_C

BRK

0
500
1000
1500
2000
2500
2715 a.a.

Protein Preferred Names	Protein Names
chromodomain-helicase-DNA-binding protein 6	ATP-dependent helicase CHD6

Related Diseases

Diseases	Alias
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Pitt-Hopkins Syndrome	PTHS Encephalopathy, Severe Epileptic, With Autonomic Dysfunction Mental Retardation, Syndromal, With Intermittent Hyperventilation Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea Pitt Hopkins Syndrome Phs Encephalopathy Severe Epileptic With Autonomic Dysfunction
Schizophrenia 8	SCZD8 Schizophrenia Susceptibility Locus, Chromosome 18-Related Schizophrenia 8 With Or Without An Affective Disorder
Hallermann-Streiff Syndrome	Francois Dyscephalic Syndrome HSS Hallermann'S Syndrome Oculomandibulofacial Syndrome Hallerman - Streiff Syndrome François Dyscephalic Syndrome Hallermann Streiff Francois Syndrome Hallermann Streiff Syndrome
Adult Spinal Cord Ependymoma
Charge Syndrome	Charge Association Hall-Hittner Syndrome Charge Association--Coloboma, Heart Anomaly, Choanal Atresia, Retardation, Genital And Ear Anomalies Hhs Coloboma, Heart Anomaly, Choanal Atresia, Restriction Of Growth And Development, Genital And Ear Anomalies Coloboma-Heart Defects-Atresia Choanae-Retardation Of Growth And Development-Genitourinary Problems-Ear Abnormalities Syndrome CHARGES

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS02611	CHD6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20705	Chd6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27216	Chd6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CHD6	MGD	MGI:1918639
Bos taurus	CHD6	VGNC	VGNC:27281
Canis familiaris	CHD6	VGNC	VGNC:39204
Felis catus	CHD6	VGNC	VGNC:60847
Macaca mulatta	CHD6	VGNC	VGNC:71022
Rattus norvegicus	CHD6	RGD	RGD:1310465
Others	CHD6	NCBI