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Gevokizumab

2 Cited Publications
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Based on 2 publication(s) in Google Scholar

Gevokizumab is a potent anti-IL-1β antibody, negatively modulates IL-1β signaling through an allosteric mechanism. Gevokizumab selectively decreases the binding affinity of IL-1β for the IL-1 receptor type I (IL-1RI) signaling receptor instead of IL-1 counter-regulatory decoy receptor (IL-1 receptor type II).

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  • Pureté : 98.12%
  • CAS No.: 1129435-60-4
  • Masse moléculaire:145.12 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Gevokizumab
  • Experimental Validation Results for Gevokizumab
  • Experimental Validation Results for Gevokizumab
  • Gevokizumab Chemical Structure
    Gevokizumab Chemical Structure
CAS No.: 1129435-60-4
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609-228-6898
[email protected] [email protected]
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Assay Types
  • 1/16

    Human IgG2 kappa

  • 1/16

    Loaded Gevokizumab on AHC2 biosensor, can bind TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78217) with an affinity constant of 6.595E-10 M as determined in BLI assay.

  • 1/16

    Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 50 nM phorbol-12-myristate-13-acetate (PMA, HY-18739) and 5 μg/ml lipopolysaccharide (LPS, HY-D1056) for 24 hours labeling Gevokizumab (HY-P99171, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG2 kappa, Isotype Control (HY-P99002, blue) was used as the isotype control ,cells without incubation with primary antibody were used as the unlabeled control (black).

  • Gevokizumab Chemical Structure
    1/16
  • Gevokizumab
  • Loaded Gevokizumab on AHC2 biosensor, can bind TIM-3/HAVCR2 Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78217) with an affinity constant of 6.595E-10 M as determined in BLI assay.
  • Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 50 nM phorbol-12-myristate-13-acetate (PMA, HY-18739) and 5 μg/ml lipopolysaccharide (LPS, HY-D1056) for 24 hours labeling Gevokizumab (HY-P99171, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG2 kappa, Isotype Control (HY-P99002, blue) was used as the isotype control ,cells without incubation with primary antibody were used as the unlabeled control (black).