IACS-56676
IACS-56676 is a selective NRASG12D inhibitor with a target IC50 of 0.031 μM. IACS-56676 stabilizes the p-loop, maintains key interactions with Asp12, Gly60 and Asp69, and achieves selectivity against wild-type KRAS through substitution targeting Leu95. IACS-56676 can be used in the research of melanoma, hematologic malignancies and thyroid cancer.
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- CAS No.: 3105153-34-9
- Formule: C28H28ClF4N5O
- Masse moléculaire:562.00
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IACS-56676 potently reduces viability of NRASG12D-mutant THP1 cells with an IC50 of 0.073 μM[1].
IACS-56676 has minimal CYP inhibition activity, with no measurable inhibition of CYP2D6 and CYP2C9 up to 10 μM, and weak inhibition of CYP3A4 isoforms[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3105153-34-9
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Masse moléculaire 562.00
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Formule C28H28ClF4N5O
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SMILES
NC1=CC(C2=C(F)C(N(C3CC3)C(CNC(C)=O)=C4[C@@]5([H])[C@@]6([H])[C@]5([H])CNC6)=C4C(C7CC7)=N2)=C(C(F)(F)F)C(Cl)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IACS-56676 Related Classifications
HY-181555 Related Classifications
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