L-364918
L-364918 is a potent and selective oxytocin and arginine vasopressin antagonist with Ki values of 30, 1300, 2400 nM for OT, AVP-V1, AVP-V2, respectively. L-364918 has the potential for the research of preterm labor and disturbances in water balance.
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- CAS No.: 122211-31-8
- Formule: C40H54N8O6
- Masse moléculaire:742.91
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Voir tous les produits spécifiques à Isoform Vasopressin Receptor
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Activité biologique
Description
IC50 & Target
[1]|
V2 Receptor 2400 nM (Ki) |
V1 receptor 1300 nM (Ki) |
oxytocin 30 nM (Ki) |
In Vitro
L-364918 (0-1 mM) inhibits AVP-stimulated accumulation of inositol phosphates dose-dependently in hepatocytes prelabeled with inositol with an IC50 value 0f 8.6 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 122211-31-8
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Masse moléculaire 742.91
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Formule C40H54N8O6
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SMILES
O=C1NC(C(CC)C)C(N2NCCCC2C(N3NCCCC3C(N(C(CC4=CC=CC=C4)C(N5CCCC5C(NC1CC6=CC=CC=C6)=O)=O)C)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-364918 Related Classifications
HY-129333 Related Classifications
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