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Linrodostat mesylate

(Synonyms: BMS-986205 mesylate; ONO-7701 mesylate)
7 Cited Publications
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Based on 7 publication(s) in Google Scholar

Linrodostat (BMS-986205) mesylate is a selective irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), which effectively inhibits IDO1-HEK293 mesylate cells with an IC50 value of 1.1 nM. Linrodostat mesylate demonstrates good pharmacological activity in advanced cancer.

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  • CAS No.: 2221034-29-1
  • Formule: C25H28ClFN2O4S
  • Masse moléculaire:507.02
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  • Linrodostat mesylate Chemical Structure
    Linrodostat mesylate Chemical Structure
  • Experimental Validation Results for Linrodostat mesylate
  • Experimental Validation Results for Linrodostat mesylate
  • Experimental Validation Results for Linrodostat mesylate
  • Experimental Validation Results for Linrodostat mesylate
CAS No.: 2221034-29-1
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  • Linrodostat mesylate Chemical Structure
    Linrodostat mesylate Chemical Structure
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    Linrodostat mesylate purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2024 Nov 28;21(1):307. [Abstract]

    Customer Validation
     linrodostat (Lin: 5 mg/kg).Immunofluorescence staining of TPH-2+ neurons and 5-HT in newborn MRN pups at P10.

  • 1/16

    Linrodostat mesylate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2024 Sep 13;43(9):114741. [Abstract]

    Customer Validation
     qPCR and ELISA of pro-/anti-inflammatory marker genes in macrophages treated with IDO1 inhibitor (LRDS: 50 nM) and IL4I1 inhibitor (CB668) followed by pro-/anti-inflammatory stimuli (n = 4). Anti-inflammatory CCL22 gene and protein levels in IL-4-activated macrophages.

  • 1/16

    Linrodostat mesylate purchased from MedChemExpress. Usage Cited in: Immunity. 2021 Oct 12;54(10):2354-2371.e8. [Abstract]

    Customer Validation
     Linear regression analysis of Ly6c+CD103+ DCs versus tumor response across graded doses of the IDO-inhibitor Linrodostat (10-5-2-0 mg/kg/day) plus CTX (given day 10) and ibrutinib (16 mg/kg/day), on a schedule similar to panel A. Regression analysis shows pooled data from all groups, measured on day 15.

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    Linrodostat mesylate purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2021 Feb;28(2):715-729. [Abstract]

    Customer Validation
     HDLECs pre-treated with indicated exosomes were cocultured with in vitro-activated CD8+ T cells at a ratio of 1:1 with or without 100 nM of an IDO inhibitor (BMS-986205). The expression of CD69.

  • Linrodostat mesylate