2221034-29-1
Chemical Structure
Linrodostat mesylate
Synonym(s): BMS-986205 mesylate; ONO-7701 mesylate
- CAS No.: 2221034-29-1
- Formula:C25H28ClFN2O4S
- Molecular Weight:507.02
IUPAC Name: (R)-N-(4-chlorophenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide methanesulfonate
InChIKey: LZNFBNWGSDOVIO-QEFLZESTSA-N
SMILES: O=C(NC1=CC=C(Cl)C=C1)[C@H](C)[C@@](CC2)([H])CC[C@H]2C3=CC=NC4=C3C=C(F)C=C4.OS(C)(=O)=O
Biological Activity: Linrodostat (BMS-986205) mesylate is a selective irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), which effectively inhibits IDO1-HEK293 mesylate cells with an IC50 value of 1.1 nM. Linrodostat mesylate demonstrates good pharmacological activity in advanced cancer[1].
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Linrodostat mesylate | Linrodostat (BMS-986205) mesylate is a selective irreversible inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), which effectively inhibits IDO1-HEK293 mesylate cells with an IC50 value of 1.1 nM. Linrodostat mesylate demonstrates good pharmacological activity in advanced cancer. | |||||||||||||||||||||
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