MDI-117740
MDI-117740 is a dual LIMK1/2 inhibitor. MDI-117740 shows effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells. MDI-117740 exerts significant anti-migratory activity in MDA-MB-231 cells. MDI-117740 can be used for the study of cancers and neurodegenerative disorders.
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- Formule: C24H24N4O2
- Masse moléculaire:400.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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LIMK1 7.80 (pKd) |
LIMK2 7.12 (pKd) |
LIMK1 6.73 (pIC50) |
LIMK2 7.18 (pIC50) |
MDI-117740 exhibits potent binding affinity to LIMK1 (pKd = 7.80) and LIMK2 (pKd = 7.12) as well as effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells[1].
MDI-117740 (2 h) potently inhibits cofilin phosphorylation (p-cofilin) in SH-SY5Y cells, with a pIC50 value of 6.89[1].
MDI-117740 (0.25-3 μM, 48 h) exerts significant anti-migratory activity in MDA-MB-231 cells via wound healing assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 400.47
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Formule C24H24N4O2
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SMILES
O=C(C1=C(CCN2[C@H](C3CC3)C4=CC=CC=C4)C(C2=O)=NN1CC5=CC=CC=C5)N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDI-117740 Related Classifications
HY-175656 Related Classifications
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