1011465-90-9
Chemical Structure
H-0106 dihydrochloride
- CAS No.: 1011465-90-9
- Formula:C16H22Cl3N3O2S
- Molecular Weight:426.79
IUPAC Name: (S)-4-chloro-5-((2-methyl-1,4-diazocan-1-yl)sulfonyl)isoquinoline dihydrochloride
InChIKey: FJTAIFQBRYJWMX-LTCKWSDVSA-N
SMILES: O=S(C1=CC=CC2=C1C(Cl)=CN=C2)(N3[C@H](CNCCCC3)C)=O.[H]Cl.[H]Cl
Biological Activity: H-0106 dihydrochloride is a ROCK inhibitor with potent intraocular pressure (IOP)-lowering activity. H-0106 dihydrochloride can effectively inhibit ROCK enzyme. H-0106 dihydrochloride demonstrated significant IOP-lowering effects in monkey eyes. Studies with H-0106 dihydrochloride suggest that there may not be a direct relationship between ROCK inhibition and IOP reduction[1].
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H-0106 dihydrochloride | H-0106 dihydrochloride is a ROCK inhibitor with potent intraocular pressure (IOP)-lowering activity. H-0106 dihydrochloride can effectively inhibit ROCK enzyme. H-0106 dihydrochloride demonstrated significant IOP-lowering effects in monkey eyes. Studies with H-0106 dihydrochloride suggest that there may not be a direct relationship between ROCK inhibition and IOP reduction. | |||||||||||||||||||||
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