102637-02-5
Chemical Structure
Methyl helicterate
- CAS No.: 102637-02-5
- Formula:C40H56O6
- Molecular Weight:632.87
IUPAC Name: methyl (1R,3aS,5aS,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-acetoxy-5a-((benzoyloxy)methyl)-5b,8,8,11a-tetramethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate
InChIKey: MYBPKOKJNVOFNJ-BIECZKHRSA-N
SMILES: CC1([C@H](CC[C@@]2([C@]3(CC[C@@]4([C@]5([C@@H](CC[C@@]5(CC[C@]4([C@@]3(CC[C@@]12[H])C)COC(C6=CC=CC=C6)=O)C(OC)=O)C(C)=C)[H])[H])[H])C)OC(C)=O)C
Biological Activity: Methyl helicterate is a triterpenoid, that can be isolated from Helicteres angustifolia (Sterculiaceae). Methyl helicterate inhibits hepatic stellate cell activation and promotes cell apoptosis through downregulating the ERK1/2 signaling pathway[1][2][3].
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Methyl helicterate | Methyl helicterate is a triterpenoid, that can be isolated from Helicteres angustifolia (Sterculiaceae). Methyl helicterate inhibits hepatic stellate cell activation and promotes cell apoptosis through downregulating the ERK1/2 signaling pathway. | |||||||||||||||||||||
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- [1]. Wei Y, et al. Methyl helicterate inhibits hepatic stellate cell activation through downregulating the ERK1/2 signaling pathway. J Cell Biochem. 2019 Sep;120(9):14936-14945. [Content Brief]
- [2]. Huang Q, et al. Effect and mechanism of methyl helicterate isolated from Helicteres angustifolia (Sterculiaceae) on hepatic fibrosis induced by carbon tetrachloride in rats. J Ethnopharmacol. 2012 Oct 11;143(3):889-95. [Content Brief]
- [3]. Chen W, et al. Pregnane, coumarin and lupane derivatives and cytotoxic constituents from Helicteres angustifolia. Phytochemistry. 2006 May;67(10):1041-7. [Content Brief]
Keywords
