108181-00-6
108181-00-6
Chemical Structure
DC_C66
- CAS No.: 108181-00-6
- Formula:C28H22NO2+
- Molecular Weight:404.48
IUPAC Name: 8-(ethoxycarbonyl)-5,6-dihydrodibenzo[f,h]isoquinolino[2,1-b]isoquinolin-7-ium
InChIKey: DIVJVPWHSSAIPN-UHFFFAOYSA-N
SMILES: O=C(OCC)C1=[N+]2C(C(C=CC=C3)=C3CC2)=CC4=C1C(C=CC=C5)=C5C6=C4C=CC=C6
Biological Activity: DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5[1].
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DC_C66 | DC_C66 is a cell-permeable, selective coactivator associated arginine methyltransferase 1 (CARM1) inhibitor with an IC50 of 1.8 μM. DC_C66 has a good selectivity for CARM1 against PRMT1 (IC50=21 μM), PRMT6 (IC50= 47μM), and PRMT5. | |||||||||||||||||||||
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References
Keywords
