108692-47-3
Chemical Structure
Nectrisine
- CAS No.: 108692-47-3
- Formula:C5H9NO3
- Molecular Weight:131.13
IUPAC Name: (2R,3R,4R)-2-(hydroxymethyl)-3,4-dihydro-2H-pyrrole-3,4-diol
InChIKey: QUPCOXZVKXONSC-UOWFLXDJSA-N
SMILES: C(O)[C@@H]1[C@@H](O)[C@H](O)C=N1
Biological Activity: Nectrisine is a competitive, targeted α-glucosidase inhibitor with an IC50 of 29 μM. Nectrisine also exhibits varying degrees of inhibitory activity against rat trimming glucosidase I, jack bean α-mannosidase, almond β-glucosidase, snail β-mannosidase, and bovine β-N-acetylglucosaminidase. Nectrisine further inhibits syncytium formation and hemolytic activity in Newcastle disease virus-infected cells, and acts as an immunomodulator to induce Ia antigen expression and restore immune responses suppressed by tumor-derived immunosuppressive factors[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Nectrisine | Nectrisine is a competitive, targeted α-glucosidase inhibitor with an IC50 of 29 μM. Nectrisine also exhibits varying degrees of inhibitory activity against rat trimming glucosidase I, jack bean α-mannosidase, almond β-glucosidase, snail β-mannosidase, and bovine β-N-acetylglucosaminidase. Nectrisine further inhibits syncytium formation and hemolytic activity in Newcastle disease virus-infected cells, and acts as an immunomodulator to induce Ia antigen expression and restore immune responses suppressed by tumor-derived immunosuppressive factors. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Tsujii E, et al. Nectrisine is a potent inhibitor of alpha-glucosidases, demonstrating activities similarly at enzyme and cellular levels. Biochemical and biophysical research communications. 1996 Mar 18;220(2):459-66. [Content Brief]
- [2]. KAYAKIRI H, et al. Structure and synthesis of nectrisine, a new immunomodulator isolated from a fungus[J]. Chemical and pharmaceutical bulletin, 1991, 39(11): 2807-2812.
- [3]. Kim Y J, et al. Synthesis of nectrisine and related compounds, and their biological evaluation[J]. Tetrahedron, 1999, 55(28): 8353-8364.
