11024-55-8
Chemical Structure
Paspalicine
- No. CAS: 11024-55-8
- Formula:C27H31NO3
- Molecular Weight:417.54
InChIKey: HSFKQYJRJBEWKH-XTHGXZEWSA-N
SMILES: C[C@@]12[C@@]3([C@](CC[C@@]1([H])CC4=C2NC5=CC=CC=C54)([H])C([C@]6(O[C@]7([H])C(C)(O6)C)CC3)=CC7=O)C
Biological Activity: Paspalicine is an indole diterpenoid fungal metabolite with no tremorgenic activity in animals. Paspalicine targets the large-conductance calcium-activated potassium (maxi-K) channel, blocks channel activity, and modulates the binding of Charybdotoxin (HY-P0191) to the maxi-K channel via a positive allosteric mechanism that enhances toxin binding. Paspalicine can be used in studies related to ryegrass staggers[1][2].
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Paspalicine | Paspalicine is an indole diterpenoid fungal metabolite with no tremorgenic activity in animals. Paspalicine targets the large-conductance calcium-activated potassium (maxi-K) channel, blocks channel activity, and modulates the binding of Charybdotoxin (HY-P0191) to the maxi-K channel via a positive allosteric mechanism that enhances toxin binding. Paspalicine can be used in studies related to ryegrass staggers. | |||||||||||||||||||||
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- [1]. Smith AB III, et al. Indole Diterpene Synthetic Studies. 8. The Total Synthesis of (+)-Paspalicine and (+)-Paspalinine. J Am Chem Soc. 1992;114(4):1438-1449.
- [2]. Knaus HG, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 1994 May 17;33(19):5819-28. [Content Brief]
Keywords
