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Cat. No.: HY-N19650

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Paspalicine

Paspalicine is an indole diterpenoid fungal metabolite with no tremorgenic activity in animals. Paspalicine targets the large-conductance calcium-activated potassium (maxi-K) channel, blocks channel activity, and modulates the binding of Charybdotoxin (HY-P0191) to the maxi-K channel via a positive allosteric mechanism that enhances toxin binding. Paspalicine can be used in studies related to ryegrass staggers.

For research use only. We do not sell to patients.

CAS No.: 11024-55-8
Formula: C₂₇H₃₁NO₃
Molecular Weight:417.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Paspalicine Chemical Structure

CAS No.: 11024-55-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Paspalicine allosterically enhances [¹²⁵I]ChTX binding to maxi-K channels in bovine aortic smooth muscle sarcolemmal membrane vesicles, with a K₁_/₂ of 100 nM and a maximum 120% increase in specific binding relative to control^[2].
Paspalicine (10 nM; measured 3 min post-exposure) potently blocks maxi-K channels in excised inside-out membrane patches from bovine aortic smooth muscle cells, with 10 nM causing 83% current block, and the block is partially reversible after washout^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 11024-55-8
Molecular Weight 417.54
Formula C₂₇H₃₁NO₃
SMILES

C[C@@]12[C@@]3([C@](CC[C@@]1([H])CC4=C2NC5=CC=CC=C54)([H])C([C@]6(O[C@]7([H])C(C)(O6)C)CC3)=CC7=O)C
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Microorganisms
Claviceps paspali
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Smith AB III, et al. Indole Diterpene Synthetic Studies. 8. The Total Synthesis of (+)-Paspalicine and (+)-Paspalinine. J Am Chem Soc. 1992;114(4):1438-1449.

[2]. Knaus HG, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 1994 May 17;33(19):5819-28. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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