1135037-53-4
Chemical Structure
NSC339614 potassium
- CAS No.: 1135037-53-4
- Formula:C10H4KN3O6S
- Molecular Weight:333.32
IUPAC Name: potassium 7-nitronaphtho[1,2-c][1,2,5]oxadiazole-5-sulfonate
InChIKey: USKSVJAMFHMGIJ-UHFFFAOYSA-M
SMILES: O=[N+](C1=CC=C2C3=NON=C3C=C(S(=O)(O[K])=O)C2=C1)[O-]
Biological Activity: NSC339614 potassium is a selective GluN1/GluN2C and GluN1/GluN2D receptor enhancer with the activity of enhancing neuronal responses to specific NMDA receptors. NSC339614 potassium can selectively enhance the signaling of GluN1/GluN2C and GluN1/GluN2D receptors without affecting other NMDA receptors. The mechanism of action of NSC339614 potassium does not compete with agonists of L-glutamate or glycine, nor does it depend on membrane potential. The activity of NSC339614 potassium depends on the specific structure of the agonist ligand binding domain, showing its potential as a novel pharmacological agent for studying the function of NMDA receptor subtypes and providing new lead compounds for a variety of neurological diseases[1].
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NSC339614 potassium | NSC339614 potassium is a selective GluN1/GluN2C and GluN1/GluN2D receptor enhancer with the activity of enhancing neuronal responses to specific NMDA receptors. NSC339614 potassium can selectively enhance the signaling of GluN1/GluN2C and GluN1/GluN2D receptors without affecting other NMDA receptors. The mechanism of action of NSC339614 potassium does not compete with agonists of L-glutamate or glycine, nor does it depend on membrane potential. The activity of NSC339614 potassium depends on the specific structure of the agonist ligand binding domain, showing its potential as a novel pharmacological agent for studying the function of NMDA receptor subtypes and providing new lead compounds for a variety of neurological diseases. | |||||||||||||||||||||
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Keywords
